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Mechanisms Controlling the Cellular Accumulation of Copper Bis(thiosemicarbazonato) Complexes

1 Sept 2011

Abstract excerpt

Copper (Cu) bis(thiosemicarbazonato) metal complexes [Cu(II)(btsc)s] have unique tumor-imaging and treatment properties and more recently have revealed potent neuroprotective actions in animal and cell models of neurodegeneration. However, despite the continued development of Cu(II)(btsc)s as potential therapeutics or diagnostic agents, little is known of the mechanisms involved in cell uptake, subcellular...

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PMID: 21882803
DOI: 10.1021/ic201334q

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