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NO modulates human airway smooth muscle function by altering glucose-6-phosphate dehydrogenase effects on sGC function in asthma

2026-05-11

Abstract excerpt

<h4>ABSTRACT</h4> Since NO can modulate mesenchymal cell function, we posit that NO can modulate gene expression associated with excitation-contraction coupling. Our study shows that treating asthma-derived HASMCs with a low dose of NO plus sGC stimulator BAY-41, in most cases sensitized smooth muscle sGC towards activation via an elevated sGC heterodimer and in some cases also improved sGCβ1, catalase, Cyb5r3 or...

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Literature Corpus work
f004b50d-100c-598a-b952-d5a9c356e378
DOI
10.64898/2026.05.06.723287
Open publication

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NO modulates human airway smooth muscle function by altering glucose-6-phosphate dehydrogenase effects on sGC function in asthmaDOI 10.64898/2026.05.06.723287
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