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Article

NO and CO differentially activate soluble guanylyl cyclase via a heme pivot-bend mechanism.

The EMBO journal - 24 Jan 2007

Ma Xiaolei, Sayed Nazish, Beuve Annie, van den Akker Focco

Abstract excerpt

Diatomic ligand discrimination by soluble guanylyl cyclase (sGC) is paramount to cardiovascular homeostasis and neuronal signaling. Nitric oxide (NO) stimulates sGC activity 200-fold compared with only four-fold by carbon monoxide (CO). The molecular details of ligand discrimination and differential response to NO and CO are not well understood. These ligands are sensed by the heme domain of sGC, which belongs to...

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Identifiers

PMID: 17215864
DOI: 10.1038/sj.emboj.7601521
PMCID: PMC1783457

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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