Article
GSNOR Deficiency Enhances In Situ Skeletal Muscle Strength, Fatigue Resistance, and RyR1 S-Nitrosylation Without Impacting Mitochondrial Content and Activity.
Antioxidants & redox signaling - 1 Feb 2017
Moon Younghye, Cao Yenong, Zhu Jingjing, Xu Yuanyuan, Balkan Wayne, Buys Emmanuel S, Diaz Francisca, Kerrick W Glenn, Hare Joshua M, Percival Justin M
Abstract excerpt
AIM: Nitric oxide (NO) plays important, but incompletely defined roles in skeletal muscle. NO exerts its regulatory effects partly though S-nitrosylation, which is balanced by denitrosylation by enzymes such as S-nitrosoglutathione reductase (GSNOR), whose functions in skeletal muscle remain to be fully deciphered. RESULTS: GSNOR null (GSNOR-/-) tibialis anterior (TA) muscles showed normal growth and were...
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