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Article

Functionally different α-synuclein inclusions yield insight into Parkinson’s disease pathology

17 Mar 2016

Abstract excerpt

The formation of α-synuclein (α-S) amyloid aggregates, called Lewy bodies (LBs), is a hallmark of Parkinson's disease (PD). The function of LBs in the disease process is however still unclear; they have been associated with both neuroprotection and toxicity. To obtain insight into this contradiction, we induced the formation of α-S inclusions, using three different induction methods in SH-SY5Y cells and...

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PMID: 26984067
DOI: 10.1038/srep23116

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