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PCSK9 affects expression of key surface proteins in human pancreatic beta cells through intra- and extracellular regulatory circuits

2021-09-28

Abstract excerpt

<h4>Aims/hypothesis</h4> Proprotein convertase subtilisin/kexin 9 (PCSK9) is involved in the degradation of LDLR. However, PCSK9 can target other proteins in a cell-type specific manner. While PCSK9 has been detected in pancreatic islets, its expression in insulin-producing pancreatic beta cells is debated. Herein, we studied PCSK9 expression, regulation and function in the human pancreatic beta cell line EndoC-β...

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Literature Corpus work
53f26906-ef6a-5e69-abaa-a2bf77e66df4
DOI
10.1101/2021.09.28.461975
Open publication

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PCSK9 affects expression of key surface proteins in human pancreatic beta cells through intra- and extracellular regulatory circuitsDOI 10.1101/2021.09.28.461975
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