Article

Autophagy Suppresses CCL2 to Preserve Appetite and Prevent Lethal Cachexia

2025-02-24

Abstract excerpt

Macroautophagy (autophagy hereafter) captures intracellular components and delivers them to lysosomes for degradation and recycling 1 . In adult mice, autophagy sustains metabolism to prevent wasting by cachexia and to survive fasting, and also suppresses inflammation, liver steatosis, neurodegeneration, and lethality 2,3 . Defects in autophagy contribute to metabolic, inflammatory and degenerative diseases, how...

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Identifiers and source

Literature Corpus work: aae81b71-b907-59d1-bb2a-fa69abd20555
DOI: 10.1101/2025.02.20.638910

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