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RNAi Library Screening Reveals Gβ1, Casein Kinase 2α and ICAP-1 as Novel Regulators of LFA-1-mediated T-cell Polarity and Migration

2024-07-16

Abstract excerpt

The αLβ2 integrin LFA-1 plays a key role in T-cell adhesion to the endothelial vasculature and migration into both secondary lymphoid organs and peripheral tissues via interactions with its target protein ICAM-1, but the pathways that regulate LFA-1-mediated T-cell polarity and migration are not fully understood. In this study we screened two RNAi libraries targeting G protein-coupled receptors (GPCR)/GPCR-associa...

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Literature Corpus work: ef714530-1d02-5f2a-95ca-2fb6f71fbbaa
DOI: 10.22541/au.172114395.55022246/v1

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RNAi Library Screening Reveals Gβ1, Casein Kinase 2α and ICAP-1 as Novel Regulators of LFA-1-mediated T-cell Polarity and MigrationDOI 10.22541/au.172114395.55022246/v1Read

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