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RNAi Library Screening Reveals Gβ 1 , Casein Kinase 2α and ICAP-1 as Novel Regulators of LFA-1-mediated T-cell Polarity and Migration

2024-01-30

Abstract excerpt

The α L β 2 integrin LFA-1 plays a key role in T-cell adhesion to the endothelial vasculature and migration into both secondary lymphoid organs and peripheral tissues via interactions with its target protein ICAM-1. Although members of the chemokine family of G-protein coupled receptors and heterotrimeric G proteins are known to influence LFA-1 activation and ICAM binding, the role of these receptors and their d...

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Literature Corpus work: 6d35e0a8-1280-503e-9fca-2479d9dbfa18
DOI: 10.22541/au.170664176.64444763/v1

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