Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Acquisition of exogenous fatty acids renders apicoplast-based biosynthesis dispensable in tachyzoites of Toxoplasma

27 Apr 2020

Abstract excerpt

Toxoplasma gondii is a common protozoan parasite that infects a wide range of hosts, including livestock and humans. Previous studies have suggested that the type 2 fatty acid synthesis (FAS2) pathway, located in the apicoplast (a nonphotosynthetic plastid relict), is crucial for the parasite's survival. Here we examined the physiological relevance of fatty acid synthesis in T. gondii by focusing on the pyruvate...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy in Disease and Therapy
Share to Peroxisome Proliferator-Activated Receptors
Share to Toxoplasma gondii Research Studies

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 32341123
DOI: 10.1074/jbc.ra120.013004

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Acquisition of exogenous fatty acids renders apicoplast-based biosynthesis dispensable in tachyzoites of ToxoplasmaPMID 32341123Read ↗

The intracellular parasite Toxoplasma gondii depends on the synthesis of long-chain and very long-chain unsaturated fatty acids not supplied by the host cell.Semantic proximity Read ↗

Toxoplasma acyl-CoA synthetase TgACS3 is crucial to channel host fatty acids in lipid droplets and for parasite propagationSemantic proximity Read ↗

The acyl-CoA synthetase Tg ACS1 allows neutral lipid metabolism and extracellular motility in Toxoplasma gondii through relocation via its peroxisomal targeting sequence (PTS) under low nutrient conditionsSemantic proximity Read ↗

An endoplasmic reticulum localized acetyl-CoA transporter is required for efficient fatty acid synthesis in Toxoplasma gondiiSemantic proximity Read ↗

Division and Adaptation to Host Environment of Apicomplexan Parasites Depend on Apicoplast Lipid Metabolic Plasticity and Host Organelle Remodeling.Semantic proximity Read ↗

<i>Toxoplasma gondii</i> Fatty Acid Elongases are Important for Virulence and PersistenceSemantic proximity Read ↗

Functional and Computational Genomics Reveal Unprecedented Flexibility in Stage-Specific Toxoplasma Metabolism.Semantic proximity Read ↗

Division and adaptation to host nutritional environment of apicomplexan parasites depend on apicoplast lipid metabolic plasticity and host organelles remodellingSemantic proximity Read ↗

Pantothenate biosynthesis is critical for chronic infection by the neurotropic parasite Toxoplasma gondiiSemantic proximity Read ↗

Metabolic Needs and Capabilities of Toxoplasma gondii through Combined Computational and Experimental Analysis.Semantic proximity Read ↗

Pyruvate Homeostasis as a Determinant of Parasite Growth and Metabolic Plasticity in Toxoplasma gondiiSemantic proximity Read ↗

Pantothenate biosynthesis is critical for chronic infection by the neurotropic parasite <i>Toxoplasma gondii</i>Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.