Article

<i>Toxoplasma gondii</i> requires its plant-like heme biosynthesis pathway for infection

2019-08-31

Abstract excerpt

Heme, an iron-enclosed organic ring, is essential for virtually all living organisms by serving as a prosthetic group in proteins that function in diverse cellular activities ranging from diatomic gas transport and detection to mitochondrial respiration to detoxification. Cellular heme levels in microbial pathogens can be a composite of endogenous de novo synthesis or exogenous uptake of heme or heme synthesis in...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 95fdf47d-a67c-5993-97c6-95c9fbd0c4d6
DOI: 10.1101/753863

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

<i>Toxoplasma gondii</i> requires its plant-like heme biosynthesis pathway for infectionDOI 10.1101/753863Read

Toxoplasma gondii requires its plant-like heme biosynthesis pathway for infectionSemantic proximity Read

The apicoplast is important for the viability and persistence of <i>Toxoplasma gondii</i> bradyzoitesSemantic proximity Read

Supply and demand—heme synthesis, salvage and utilization by ApicomplexaSemantic proximity Read

Differential contribution of two organelles of endosymbiotic origin to iron-sulfur cluster synthesis and overall fitness in ToxoplasmaSemantic proximity Read

Parasite powerhouse: A review of the Toxoplasma gondii mitochondrionSemantic proximity Read

The vacuolar iron transporter mediates iron detoxification in Toxoplasma gondiiSemantic proximity Read

Malaria, <i>Plasmodium falciparum</i> and its apicoplastSemantic proximity Read

Host cell metabolism contributes to delayed-death kinetics of apicoplast inhibitors in <i>Toxoplasma gondii</i>Semantic proximity Read

New paradigms for understanding and step changes in treating active and chronic, persistent apicomplexan infectionsSemantic proximity Read

Differential contribution of two organelles of endosymbiotic origin to iron-sulfur cluster synthesis and overall fitness in ToxoplasmaSemantic proximity Read

Disrupting the plastidic iron-sulfur cluster biogenesis pathway in Toxoplasma gondii has pleiotropic effects irreversibly impacting parasite viabilitySemantic proximity Read

Metabolic interactions between Toxoplasma gondii and its hostSemantic proximity Read