Article

Structural evolution of the estrogen receptor regulatory domain

2025-01-04

Abstract excerpt

Estrogen receptors (ERs) α, β and γ are ligand-dependent transcription factors that regulate vertebrate reproduction, cell survival and other physiological processes. Here, we report an integrative analysis of mammalian and teleost receptors, including the first structure of an ERγ ligand binding domain (LBD), showing that structural divergence acquired during evolution is accommodated by different strategies with...

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Identifiers and source

Literature Corpus work: ef61ba5e-0a34-5fee-9ff9-53ad09edf20e
DOI: 10.1101/2024.12.18.629305

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