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NRF1-Mediated Oncogenic Reprogramming Drives Estrogen-Induced Breast Carcinogenesis

2018-09-11

Abstract excerpt

Transcription factor activity of the nuclear respiratory factor 1 protein (NRF1) is increased in breast cancer. Whether this gain of NRF1 activity is directly involved in breast cancer remains unknown. Herein, we report a novel oncogenic function of NRF1 supporting its causative role in breast cancer development and progression. The gain of NRF1 and/or treatment with 17β-estradiol (E2) produced heterogeneous...

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Literature Corpus work
ef5e95ca-0b70-5a25-98c8-b43920ae0ebd
DOI
10.20944/preprints201809.0183.v1
Open publication

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NRF1-Mediated Oncogenic Reprogramming Drives Estrogen-Induced Breast CarcinogenesisDOI 10.20944/preprints201809.0183.v1
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