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Article

Emerging Role of NRF2 Signaling in Cancer Stem Cell Phenotype.

Molecules and cells - 31 Mar 2023

Hallis Steffanus P, Kim Jin Myung, Kwak Mi-Kyoung

Abstract excerpt

Cancer stem cells (CSCs) are a small population of tumor cells characterized by self-renewal and differentiation capacity. CSCs are currently postulated as the driving force that induces intra-tumor heterogeneity leading to tumor initiation, metastasis, and eventually tumor relapse. Notably, CSCs are inherently resistant to environmental stress, chemotherapy, and radiotherapy due to high levels of antioxidant...

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Identifiers

PMID: 36994474
DOI: 10.14348/molcells.2023.2196
PMCID: PMC10070166

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