Article

A modular platform to generate functional sympathetic neuron-innervated heart assembloids

2026-01-26

Abstract excerpt

<title>Abstract</title> <p>The technology of human pluripotent stem cell (hPSC)-based 3D organoid/assembloid cultures has become a powerful tool for the study of human embryonic development, disease modeling and drug discovery in recent years. The autonomic sympathetic nervous system innervates and regulates almost all organs in the body, including the heart. Yet, most reported organoids to date are not innervate...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: dd9cf06d-94d5-52ca-89e8-97ba61235b07
DOI: 10.21203/rs.3.rs-3894397/v2

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A modular platform to generate functional sympathetic neuron-innervated heart assembloidsDOI 10.21203/rs.3.rs-3894397/v2Read

A modular platform to generate functional sympathetic neuron-innervated heart assembloidsSemantic proximity Read

Generation of parasympathetic neurons from hiPSC that reproduce the electrophysiological properties of native neurons and modulate the activity of hiPSC-atrial cardiomyocytesSemantic proximity Read

Functional Coupling with Cardiac Muscle Promotes Maturation of hPSC-Derived Sympathetic Neurons.Semantic proximity Read

Self-organizing human heart assembloids with autologous and developmentally relevant cardiac neural crest-derived tissuesSemantic proximity Read

Sympathetic-like-Integrated Engineered Heart Tissue Models AGEs-Induced Adverse RemodelingSemantic proximity Read

Human induced pluripotent stem cell-derived cardiac myocytes and sympathetic neurons in disease modelling.Semantic proximity Read

Pathways regulating the excitability of sympathetic neurons derived from human induced pluripotent stem cellsSemantic proximity Read

Tiered Sympathetic Control of Cardiac Function Revealed by Viral Tracing and Single Cell Transcriptome ProfilingSemantic proximity Read

Brainstem organoids from human pluripotent stem cells contain neural crest populationSemantic proximity Read

A spatially-tracked single cell transcriptomics map of neuronal networks in the intrinsic cardiac nervous systemSemantic proximity Read

Subtype-specific differentiation of cardiac pacemaker cell clusters from human induced pluripotent stem cellsSemantic proximity Read

Novel target identification using single cell sequencing and electrophysiology of cardiac sympathetic neurons in diseaseSemantic proximity Read