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Article

Functional Coupling with Cardiac Muscle Promotes Maturation of hPSC-Derived Sympathetic Neurons.

Cell stem cell - 7 Jul 2016

Oh Yohan, Cho Gun-Sik, Li Zhe, Hong Ingie, Zhu Renjun, Kim Min-Jeong, Kim Yong Jun, Tampakakis Emmanouil, Tung Leslie, Huganir Richard, Dong Xinzhong, Kwon Chulan, Lee Gabsang

Abstract excerpt

Neurons derived from human pluripotent stem cells (hPSCs) are powerful tools for studying human neural development and diseases. Robust functional coupling of hPSC-derived neurons with target tissues in vitro is essential for modeling intercellular physiology in a dish and to further translational studies, but it has proven difficult to achieve. Here, we derive sympathetic neurons from hPSCs and show that they...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27320040
DOI: 10.1016/j.stem.2016.05.002
PMCID: PMC4996639

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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