Human induced pluripotent stem cell-derived cardiac myocytes and sympathetic neurons in disease modelling.

doi:10.1098/rstb.2022.0173

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Article

Human induced pluripotent stem cell-derived cardiac myocytes and sympathetic neurons in disease modelling.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences - 19 Jun 2023

Li Ni, Edel Michael, Liu Kun, Denning Chris, Betts Jacob, Neely Oliver C, Li Dan, Paterson David J

Abstract excerpt

Human induced pluripotent stem cells (hiPSC) offer an unprecedented opportunity to generate model systems that facilitate a mechanistic understanding of human disease. Current differentiation protocols are capable of generating cardiac myocytes (hiPSC-CM) and sympathetic neurons (hiPSC-SN). However, the ability of hiPSC-derived neurocardiac co-culture systems to replicate the human phenotype in disease modelling...

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PMID: 37122212
DOI: 10.1098/rstb.2022.0173
PMCID: PMC10150199

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