Article

Spatial transcriptomics for profiling the tropism of viral vectors in tissues

2023-01-16

Abstract excerpt

<title>Abstract</title> <p>A barrier to advancing engineered adeno-associated viral vectors (AAVs) for precision access to cell subtypes is a lack of high-throughput, high-resolution assays to characterize in vivo transduction profiles. We developed an ultrasensitive, sequential fluorescence in situ hybridization (USeqFISH) method for spatial transcriptomic profiling of endogenous and viral RNA with a short barco...

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Literature Corpus work: ef3da97f-3080-55b0-b876-e482323be294
DOI: 10.21203/rs.3.rs-1486912/v1

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