Article

Functional enhancer elements drive subclass-selective expression from mouse to primate neocortex

2019-02-19

Abstract excerpt

<h4>Summary</h4> Viral genetic tools to target specific brain cell types in humans and non-genetic model organisms will transform basic neuroscience and targeted gene therapy. Here we used comparative epigenetics to identify thousands of human neuronal subclass-specific putative enhancers to regulate viral tools, and 34% of these were conserved in mouse. We established an AAV platform to evaluate cellular specifi...

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Literature Corpus work: a35fefb0-efc6-5b93-9db9-d806833c2552
DOI: 10.1101/555318

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