Comparative Analysis of AAV Serotypes for Transduction of Olfactory Sensory Neurons

Abstract excerpt

Olfactory sensory neurons within the nasal epithelium detect volatile odorants and relay odor information to the central nervous system. Unlike other sensory inputs, olfactory sensory neurons interface with the external environment and project their axons directly into the central nervous system. The use of adeno-associated viruses to target these neurons has garnered interest for applications in gene therapy, pro...

Topics

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• Axons
• COVID-19
• CRISPR and Genetic Engineering
• Cytomegalovirus and herpesvirus research
• RNA regulation and disease
• Single-cell and spatial transcriptomics
• Viral Infections and Immunology Research
• Virus-based gene therapy research

Identifiers and source

Literature Corpus work

599c495a-d280-5299-8d33-a54a9d5be0a8

DOI

10.1101/2024.09.26.615247