Article

Deep learning-guided design of cell type-specific AAV promoters

2026-01-14

Abstract excerpt

Precise cell type targeting is critical for both clinical and experimental applications of adeno-associated viral (AAV) vectors, yet engineering vectors with cell type-specific activity remains a challenge. Here, we compared three strategies leveraging single-cell chromatin accessibility data to design cell type-specific AAV promoters, including a deep learning-based method to generate de novo regulatory sequences...

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Literature Corpus work: 88dd2b76-1298-5f7c-b0ae-2193c2edfc91
DOI: 10.64898/2026.01.13.699371

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