Article

Up, up, down, down: the structural biology of the SARS-CoV-2 spike protein and how it cheats the immune system

2024-04-02

Abstract excerpt

Spike proteins protrude from the SARS-CoV-2 viral envelope and are responsible for initiating fusion into human epithelial cells by binding Angiotensin-Converting Enzyme 2 receptors on the host cell surface. Due to their exposed location on the outside of the virion and their key role in infection, SARS-CoV-2 spike proteins are an important target for vaccine development and drug design. Over the last two years, m...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c3ed473e-1532-5253-9a28-cce816b06a58
DOI: 10.1080/0889311x.2024.2363756

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Up, up, down, down: the structural biology of the SARS-CoV-2 spike protein and how it cheats the immune systemDOI 10.1080/0889311x.2024.2363756Read

Structure-function relations of the SARS-CoV-2 spike protein and impact of mutations in the variants of concern.Semantic proximity Read

A Comprehensive Analysis of Structural and Functional Changes Induced by SARS-CoV-2 Spike Protein MutationsSemantic proximity Read

A Comprehensive Analysis of Structural and Functional Changes Induced by SARS-CoV-2 Spike Protein MutationsSemantic proximity Read

Lys417 acts as a molecular switch that regulates the conformation of SARS-CoV-2 spike proteinSemantic proximity Read

Spike Proteins of SARS –CoV-2: a detailed perspective on structure, receptor binding, antigenicity, vaccine development and neutralizationSemantic proximity Read

What makes SARS‐CoV‐2 unique? Focusing on the spike proteinSemantic proximity Read

The SARS-CoV-2 Spike Glycoprotein as a Drug and Vaccine Target: Structural Insights into Its Complexes with ACE2 and AntibodiesSemantic proximity Read

Spike protein of SARS-CoV-2 variants: a brief review and practical implications.Semantic proximity Read

Comprehensive Structural and Molecular Comparison of Spike Proteins of SARS-CoV-2, SARS-CoV and MERS-CoV, and Their Interactions with ACE2Semantic proximity Read

Mechanism and evolution of human ACE2 binding by SARS-CoV-2 spikeSemantic proximity Read

Architects of infection: A structural overview of SARS-related coronavirus spike glycoproteinsSemantic proximity Read

Considerations around the SARS-CoV-2 Spike Protein with Particular Attention to COVID-19 Brain Infection and Neurological SymptomsSemantic proximity Read