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Lys417 acts as a molecular switch that regulates the conformation of SARS-CoV-2 spike protein

22 Nov 2023

Abstract excerpt

SARS-CoV-2 spike protein plays a key role in mediating viral entry and inducing host immune responses. It can adopt either an open or closed conformation based on the position of its receptor-binding domain (RBD). It is yet unclear what causes these conformational changes or how they influence the spike's functions. Here, we show that Lys417 in the RBD plays dual roles in the spike's structure: it stabilizes the...

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PMID: 37991488
DOI: 10.7554/elife.74060

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