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The Development of an AAV-Based CRISPR SaCas9 Genome Editing System That Can Be Delivered to Neurons in vivo and Regulated via Doxycycline and Cre-Recombinase

13 Nov 2018

Abstract excerpt

The RNA-guided Cas9 nuclease, from the type II prokaryotic Clustered Regularly Interspersed Short Palindromic Repeats (CRISPR) adaptive immune system has been adapted by scientists to enable site specific genome editing of eukaryotic cells both in vitro and in vivo. Previously, we reported the development of an Adeno-Associated Virus (AAV) mediated CRISPR S. pyogenes (Sp) Cas9 system, in which the genome editing...

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PMID: 30483052
DOI: 10.3389/fnmol.2018.00413

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