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Epigenetic editing alleviates Angelman syndrome phenotype in mice by unsilencing paternal Ube3a

17 Sept 2024

Abstract excerpt

Angelman syndrome (AS) is characterized by severe neurodevelopmental disorders caused by abnormalities in the maternally inherited UBE3A gene, leading to a complete loss of UBE3A specifically in neurons, where the intact paternal UBE3A is silenced by an endogenous antisense long-noncoding RNA known as UBE3A-ATS . The expression of UBE3A-ATS is regulated by the imprinting center Snrpn ( Snrpn -IC) 1 , which is...

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PMID: 39285194
DOI: 10.1038/s41421-024-00727-3

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Epigenetic editing alleviates Angelman syndrome phenotype in mice by unsilencing paternal Ube3aPMID 39285194Read ↗

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