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Article

Persistent repression of tau in the brain using engineered zinc finger protein transcription factors

19 Mar 2021

Abstract excerpt

at the transcriptional level using gene-silencing zinc finger protein transcription factors (ZFP-TFs). Following a single administration of adeno-associated virus (AAV), either locally into the hippocampus or intravenously to enable whole-brain transduction, we selectively reduced tau messenger RNA and protein by 50 to 80% out to 11 months, the longest time point studied. Sustained tau lowering was achieved...

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PMID: 33741591
DOI: 10.1126/sciadv.abe1611

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