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Article

Synthetic zinc finger repressors reduce mutant huntingtin expression in the brain of R6/2 mice.

Proceedings of the National Academy of Sciences of the United States of America - 6 Nov 2012

Garriga-Canut Mireia, Agustín-Pavón Carmen, Herrmann Frank, Sánchez Aurora, Dierssen Mara, Fillat Cristina, Isalan Mark

Abstract excerpt

Huntington's disease (HD) is a dominantly inherited neurodegenerative disorder caused by expanded CAG repeats in the huntingtin (HTT) gene. Although several palliative treatments are available, there is currently no cure and patients generally die 10-15 y after diagnosis. Several promising approa...

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Source

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Identifiers

PMID: 23054839
DOI: 10.1073/pnas.1206506109
PMCID: PMC3494930

Genes

HTT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23054839-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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