Article

Genetic architecture of the murine serum metabolome reveals carboxyl esterases as master regulators of circulating fatty acid metabolism

2026-06-28

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> The systemic biochemical diversity of circulating metabolites and lipids reflects the integrated effects of genetic variation and environmental exposure. Metabolite quantitative trait locus (mQTL) studies in humans have established gene-metabolite associations, but genetic contributions can be obscured by sex, diet, age, medication use, and environmental exposures. Genetical...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ef038ea0-b1ea-5db6-aacf-72092cdaeac7
DOI: 10.64898/2026.06.22.733914

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Genetic architecture of the murine serum metabolome reveals carboxyl esterases as master regulators of circulating fatty acid metabolismDOI 10.64898/2026.06.22.733914Read

Genetic Regulation of Plasma Lipid Species and Their Association with Metabolic PhenotypesSemantic proximity Read

Systems Analyses Reveal Physiological Roles and Genetic Regulators of Liver Lipid Species.Semantic proximity Read

Identification of genetic drivers of plasma lipoproteins in the Diversity Outbred mouse populationSemantic proximity Read

Pleiotropic and sex-specific genetic architecture of circulating metabolic markersSemantic proximity Read

Identification of genetic drivers of plasma lipoprotein size in the Diversity Outbred mouse population.Semantic proximity Read

Sex-specific lipid-mediated mechanisms drive MASLD progression revealed by paired liver–blood multi-omicsSemantic proximity Read

Genetic regulation of mouse liver metabolite levels.Semantic proximity Read

A Genome-wide Association Study Discovers 46 Loci of the Human Metabolome in the Hispanic Community Health Study/Study of Latinos.Semantic proximity Read

Proteome-wide QTL mapping enables gene-protein-phenotype metabolic network construction in a genetically diverse MASLD mouse modelSemantic proximity Read

Flexibility of a mammalian lipidome — insights from mouse lipidomicsSemantic proximity Read

Longitudinal analysis of genetic and environmental interplay in human metabolic profiles and the implication for metabolic healthSemantic proximity Read

Primary-Level Meta-Analysis of Diversity Outbred Mice Identifies a Fasting Plasma Trimethylamine N-Oxide (TMAO) Locus Modified by Sex and DietSemantic proximity Read