Article

Sex-specific lipid-mediated mechanisms drive MASLD progression revealed by paired liver–blood multi-omics

2026-04-18

Abstract excerpt

Metabolic dysfunction-associated steatotic liver disease (MASLD) exhibits marked heterogeneity and sex differences, yet the molecular mechanisms underlying disease progression remain incompletely understood. Here, we present the largest integrative multi-omics study to date combining matched liver tissue and blood profiling in 211 biopsy-confirmed, morbidly obese individuals with MASLD undergoing bariatric surgery...

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Literature Corpus work: 5f878218-1c94-567d-a67e-ec4b1a5270c5
DOI: 10.64898/2026.04.16.26351046

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