Article

Whole-exome sequencing in 16,511 individuals reveals a role of the HTRA1 protease and its substrate EGFL8 in brain white matter hyperintensities

2021-03-29

Abstract excerpt

<h4>ABSTRACT</h4> White matter hyperintensities (WMH) are among the most common radiological abnormalities in the ageing population and an established risk factor for stroke and dementia. While common variant association studies have revealed multiple genetic loci with an influence on WMH volume, the contribution of rare variants to WMH burden in the general population remains largely unexplored. We conducted a co...

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Literature Corpus work: 61447e77-608e-5a75-8758-8ee8fc6e4837
DOI: 10.1101/2021.03.26.21253954

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