Article

<i>NOTCH3</i> variants are common in the general population and associated with stroke and vascular dementia: an analysis of 200,000 participants

2020-12-14

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Cysteine-altering NOTCH3 variants identical to those causing the rare monogenic form of stroke, CADASIL, have been reported more common than expected in the general population, but their clinical significance and contribution to stroke and dementia risk in the community remains unclear. <h4>Methods</h4> Cysteine-altering NOTCH3 variants were identified in UK Biobank whole-exom...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: dfd3fb9f-de50-599f-9afc-a538c859821a
DOI: 10.1101/2020.12.14.20248151

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

<i>NOTCH3</i> variants are common in the general population and associated with stroke and vascular dementia: an analysis of 200,000 participantsDOI 10.1101/2020.12.14.20248151Read

NOTCH3 variants are more common than expected in the general population and associated with stroke and vascular dementia: an analysis of 200 000 participants.Semantic proximity Read

Broad phenotype of cysteine-altering NOTCH3 variants in UK Biobank: CADASIL to nonpenetrance.Semantic proximity Read

Cysteine-Altering NOTCH3 Variants Are a Risk Factor for Stroke in the Elderly Population.Semantic proximity Read

NOTCH3 cysteine-altering variant is an important risk factor for stroke in the Taiwanese population.Semantic proximity Read

Genetic spectrum of NOTCH3 and clinical phenotype of CADASIL patients in different populations.Semantic proximity Read

Effect of NOTCH3 EGFr Group, Sex, and Cardiovascular Risk Factors on CADASIL Clinical and Neuroimaging Outcomes.Semantic proximity Read

Clinical features and spectrum of NOTCH3 variants in Finnish patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).Semantic proximity Read

Rare NOTCH3 Variants in a Chinese Population-Based Cohort and Its Relationship With Cerebral Small Vessel Disease.Semantic proximity Read

Clinical and neuroradiological spectrum of biallelic variants in NOTCH3.Semantic proximity Read

Phenotypes Associated with NOTCH3 Cysteine-Sparing Mutations in Patients with Clinical Suspicion of CADASIL: A Systematic Review.Semantic proximity Read

Contribution of the APOE Genotype to Cognitive Impairment in Individuals With NOTCH3 Cysteine-Altering Variants.Semantic proximity Read

Comparison of clinical and neuroimaging features between NOTCH3 mutations and nongenetic spontaneous intracerebral haemorrhage.Semantic proximity Read