Article
Elucidating p53's physiological and tumourigenic roles
2020-01-01
Abstract excerpt
The key role of p53 as a tumour suppressor is widely acknowledged and based on many observations that p53 suppresses oncogene-mediated transformation of rodent fibroblasts and is the most frequently mutated gene in human cancers. However, the p53 family of transcription factors is evolutionarily very ancient and already found in primordial metazoans where it acts as a pivotal coordinator of reparative responses to...
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Identifiers and source
- Literature Corpus work
- eecfd814-b2ad-5121-8a25-8f7499de2f0c
- DOI
- 10.17863/cam.55017