Article
p53 and human cancers.
British medical bulletin - 1 Jul 1994
Lane D P
Abstract excerpt
Mutations in the p53 gene are one of the commonest specific genetic changes found in human cancer. The p53 gene is not required for normal development but lack of p53 function confers an enormously elevated risk of developing cancer, thus it seems truly to act as a tumour suppressor gene. The p53 protein is normally present in minute amounts in cells but when cells are exposed to genotoxic stimuli p53 levels rise...
Topics
- Gene Expression Regulation, Neoplastic
- Genes, Tumor Suppressor
- Genes, p53
- Humans
- Mutation
- Neoplasms
- Tumor Suppressor Protein p53