Cancer progression and p53.

doi:10.1016/s0140-6736(95)91693-8

Back to search

Article

Cancer progression and p53.

Lancet (London, England) - 14 Oct 1995

Carson D A, Lois A

Abstract excerpt

In a complex organism, somatic cells are under intermittent selection pressure for the emergence of mutants that can survive environmental insults and that can grow autonomously despite adverse conditions. Repeated rounds of mutation, selection, and proliferation may lead to cancer. The organism...

Topics

Animals
Apoptosis
Cell Transformation, Neoplastic
DNA Damage
Genes, p53
Humans
Mutation
Neoplasms

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.