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Article

Cancer progression and p53.

Lancet (London, England) - 14 Oct 1995

Carson D A, Lois A

Abstract excerpt

In a complex organism, somatic cells are under intermittent selection pressure for the emergence of mutants that can survive environmental insults and that can grow autonomously despite adverse conditions. Repeated rounds of mutation, selection, and proliferation may lead to cancer. The organism prevents malignant transformation by assuring accurate DNA repair before cell division, by forcing the death of cells...

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PMID: 7475551
DOI: 10.1016/s0140-6736(95)91693-8

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