Article
Putting p53 in Context.
Cell - 7 Sept 2017
Kastenhuber Edward R, Lowe Scott W
Abstract excerpt
TP53 is the most frequently mutated gene in human cancer. Functionally, p53 is activated by a host of stress stimuli and, in turn, governs an exquisitely complex anti-proliferative transcriptional program that touches upon a bewildering array of biological responses. Despite the many unveiled facets of the p53 network, a clear appreciation of how and in what contexts p53 exerts its diverse effects remains...
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