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Article

Exacerbated inflammatory signaling underlies aberrant response to BMP9 in pulmonary arterial hypertension lung endothelial cells.

Angiogenesis - 1 Nov 2020

Szulcek Robert, Sanchez-Duffhues Gonzalo, Rol Nina, Pan Xiaoke, Tsonaka Roula, Dickhoff Chris, Yung Lai Ming, Manz Xue D, Kurakula Kondababu, Kiełbasa Szymon M, Mei Hailiang, Timens Wim, Yu Paul B, Bogaard Harm-Jan, Goumans Marie-José

Abstract excerpt

Imbalanced transforming growth factor beta (TGFβ) and bone morphogenetic protein (BMP) signaling are postulated to favor a pathological pulmonary endothelial cell (EC) phenotype in pulmonary arterial hypertension (PAH). BMP9 is shown to reinstate BMP receptor type-II (BMPR2) levels and thereby mitigate hemodynamic and vascular abnormalities in several animal models of pulmonary hypertension (PH). Yet, responses...

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Identifiers

PMID: 32813135
DOI: 10.1007/s10456-020-09741-x
PMCID: PMC7524846

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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