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Article

The molecular basis of pyrazinamide activity on Mycobacterium tuberculosis PanD.

Nature communications - 17 Jan 2020

Sun Qingan, Li Xiaojun, Perez Lisa M, Shi Wanliang, Zhang Ying, Sacchettini James C

Abstract excerpt

Pyrazinamide has been a mainstay in the multidrug regimens used to treat tuberculosis. It is active against the persistent, non-replicating mycobacteria responsible for the protracted therapy required to cure tuberculosis. Pyrazinamide is a pro-drug that is converted into pyrazinoic acid (POA) by pyrazinamidase, however, the exact target of the drug has been difficult to determine. Here we show the enzyme PanD...

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Identifiers

PMID: 31953389
DOI: 10.1038/s41467-019-14238-3
PMCID: PMC6969166

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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