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Article

Structure activity relationship of pyrazinoic acid analogs as potential antimycobacterial agents.

Bioorganic & medicinal chemistry - 15 Nov 2022

Hegde Pooja V, Aragaw Wassihun W, Cole Malcolm S, Jachak Gorakhnath, Ragunathan Priya, Sharma Sachin, Harikishore Amaravadhi, Grüber Gerhard, Dick Thomas, Aldrich Courtney C

Abstract excerpt

Tuberculosis (TB) remains a leading cause of infectious disease-related mortality and morbidity. Pyrazinamide (PZA) is a critical component of the first-line TB treatment regimen because of its sterilizing activity against non-replicating Mycobacterium tuberculosis (Mtb), but its mechanism of action has remained enigmatic. PZA is a prodrug converted by pyrazinamidase encoded by pncA within Mtb to the active...

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Identifiers

PMID: 36228522
DOI: 10.1016/j.bmc.2022.117046
PMCID: PMC10551889

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