Article

An automated pipeline for extracting histological stain area fraction for voxelwise quantitative MRI-histology comparisons

2022-02-10

Abstract excerpt

The acquisition of MRI and histology in the same post-mortem tissue sample enables direct correlation between MRI and histologically-derived parameters. However, there still lacks a standardised automated pipeline to process histology data, with most studies relying on heavy manual intervention. Here, we introduce an automated pipeline to extract a quantitative histological measure for staining density (stain area...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: eeafcc79-b0d4-5333-ae31-1f2059c008d7
DOI: 10.1101/2022.02.10.479718

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

An automated pipeline for extracting histological stain area fraction for voxelwise quantitative MRI-histology comparisonsDOI 10.1101/2022.02.10.479718Read

Precise MRI-Histology Coregistration of Paraffin-Embedded Tissue with Blockface ImagingSemantic proximity Read

A next-generation, histological atlas of the human brain and its application to automated brain MRI segmentationSemantic proximity Read

Three-dimensional histology reveals dissociable human hippocampal long axis gradients of Alzheimer’s pathologySemantic proximity Read

Diffusion-relaxation MRI as virtual histology: separable microstructural signatures of AD pathology in ex vivo human brainSemantic proximity Read

A novel automated morphological analysis of microglia activation using a deep learning assisted modelSemantic proximity Read

Cellular deconvolution of the brain with topological magnetic resonance image analysisSemantic proximity Read

Separable multidimensional MRI signatures of cellular and structural pathology in Alzheimer’s diseaseSemantic proximity Read

Automated segmentation by deep learning of neuritic plaques and neurofibrillary tangles in brain sections of Alzheimer’s Disease PatientsSemantic proximity Read

Microglial MorphOMICs unravel region- and sex-dependent morphological phenotypes from postnatal development to degenerationSemantic proximity Read

The myelin water imaging transcriptome: myelin water fraction regionally varies with oligodendrocyte-specific gene expressionSemantic proximity Read

An image segmentation pipeline optimized for human microglia uncovers sources of morphological diversity in Alzheimer’s diseaseSemantic proximity Read

The impact of B <sub>1</sub> <sup>+</sup> inhomogeneity on image quality metrics and morphometric statistical inferences at 7 T MRISemantic proximity Read