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Three-dimensional histology reveals dissociable human hippocampal long axis gradients of Alzheimer’s pathology

2023-12-07

Abstract excerpt

<h4>INTRODUCTION</h4> Three-dimensional (3D) histology analyses are essential to overcome sampling variability and understand pathological differences beyond the dissection axis. We present Path2MR, the first pipeline allowing 3D reconstruction of sparse human histology without an MRI reference. We implemented Path2MR with post-mortem hippocampal sections to explore pathology gradients in Alzheimer’s Disease. <h4...

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Literature Corpus work
6da2cc7f-bda6-53d0-9fe8-9115b01257f2
DOI
10.1101/2023.12.05.570038
Open publication

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Three-dimensional histology reveals dissociable human hippocampal long axis gradients of Alzheimer’s pathologyDOI 10.1101/2023.12.05.570038
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