Article

Tryptophan residues in TDP-43 and SOD1 mediate the cross-seeding and toxicity of SOD1

2020-07-28

Abstract excerpt

<h4>ABSTRACT</h4> Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease of motor neurons. Neuronal superoxide dismutase-1 (SOD1) inclusion bodies are characteristic of familial ALS with SOD1 mutations, while a hallmark of sporadic ALS is inclusions containing aggregated wild-type TAR DNA-binding protein 43 (TDP-43). Co-expression of mutant or wild-type TDP-43 with SOD1 leads to misfolding of en...

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Literature Corpus work: eea77144-8d38-54bc-96e2-08fe44a51b6f
DOI: 10.1101/2020.07.27.224188

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