Article

Rational Generation of Monoclonal Antibodies and Intrabodies Selective for Pathogenic TDP-43

2025-06-14

Abstract excerpt

<h4>ABSTRACT</h4> TAR DNA-binding protein 43 (TDP-43), encoded by the TARDBP gene, is a ribonucleoprotein associated with the pathogenesis of amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and Alzheimer’s disease (AD). Under physiological conditions, TDP-43 is predominantly localized in the nucleus, where it participates in a variety of cellular functions related to RNA splicing, transport,...

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Literature Corpus work: 5320b6e4-df38-5283-8f3d-e7837a9d480f
DOI: 10.1101/2025.06.10.658846

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