Article

Amisodin alleviates TDP-43-associated ALS pathology by inhibiting the trimeric SOD1

2026-02-09

Abstract excerpt

<title>Abstract</title> <p> <bold>Background</bold> Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by the progressive loss of motor neurons, in which aggregations of TDP-43 and SOD1 represents a central pathogenic hallmark. Despite both proteins constitute major genetic and molecular determinants of ALS, the mechanistic link these two hallmark proteins remain poorly unde...

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Literature Corpus work: 7dba3eb1-d55c-5d27-9fe4-a91669cd6ef9
DOI: 10.21203/rs.3.rs-8693611/v1

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