Article

Extrafollicular B cell responses are associated with autoreactivity against the slit diaphragm in idiopathic podocytopathies

2025-09-10

Abstract excerpt

<h4>ABSTRACT</h4> Idiopathic podocytopathies lack mechanistic biomarkers and rely on empirical immunosuppression, yet the recent discovery of autoantibodies against slit diaphragm proteins implicates podocyte-directed autoimmunity as a driver of podocyte injury. However, the immune mechanisms underlying autoreactivity and phenotypic heterogeneity, particularly across age groups, remain unclear. Here, we identify...

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Literature Corpus work: eea4dccc-61e7-5d16-9394-edcce9fd2b39
DOI: 10.1101/2025.09.06.674608

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Extrafollicular B cell responses are associated with autoreactivity against the slit diaphragm in idiopathic podocytopathiesDOI 10.1101/2025.09.06.674608Read

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