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Article

Detailed Pathophysiology of Minimal Change Disease: Insights into Podocyte Dysfunction, Immune Dysregulation, and Genetic Susceptibility.

International journal of molecular sciences - 13 Nov 2024

Roman Maja, Nowicki Michał

Abstract excerpt

Minimal Change Disease (MCD) is a predominant cause of idiopathic nephrotic syndrome in the pediatric population, yet presents significant clinical challenges due to its frequent relapses and steroid resistance. Despite its relatively benign histological appearance, MCD is characterized by severe proteinuria, hypoalbuminemia, and edema, which may affect patient outcomes. Current treatment strategies primarily...

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Genetic Predisposition to Disease
Membrane Proteins
Podocytes

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39596249
DOI: 10.3390/ijms252212174
PMCID: PMC11595011

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