The autoimmune architecture of childhood idiopathic nephrotic syndrome.

Abstract excerpt

Idiopathic nephrotic syndrome, the most common glomerular disorder in children, has long been considered an immune-mediated disease based on the efficacy of glucocorticoids at inducing remission. Nevertheless, the immune processes leading to podocytopathy have largely remained elusive. The success of B-cell depletion with rituximab, descriptions of B-cell dysregulation during active disease, and the most recent...

Topics

• Humans
• Nephrotic Syndrome
• Podocytes
• Child
• B-Lymphocytes
• Autoantibodies
• Autoimmunity