Article

Intrathymic differentiation of natural antibody-producing plasma cells in human neonates

2020-08-24

Abstract excerpt

<title>Abstract</title> <p>The thymus is a central lymphoid organ responsible for the development of T cells. Here, we show that the thymus of human neonates also contains a consistent contingent of CD138+ plasma cells, producing all classes and subclasses of immunoglobulins with the exception of IgD. These antibody-secreting cells (ASC) are comprised within a larger subset of B cells lacking expression of the co...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 66f548ad-184a-5e31-94b3-25542dfac02b
DOI: 10.21203/rs.3.rs-58978/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Intrathymic differentiation of natural antibody-producing plasma cells in human neonatesDOI 10.21203/rs.3.rs-58978/v1Read

Mapping the developing human immune system across organsSemantic proximity Read

In-Depth Analysis of Human Neonatal and Adult IgM Antibody RepertoiresSemantic proximity Read

Clinical Aspects of B Cell Immunodeficiencies: The Past, the Present and the FutureSemantic proximity Read

Transcriptome profiling of human thymic CD4+ and CD8+ T cells compared to primary peripheral T cellsSemantic proximity Read

Multi-omic profiling of human antibody-secreting cells reveals diverse subsets sustain durable humoral immunitySemantic proximity Read

Multi-omic profiling of human thymic B cells reveals intrathymic Ig-class switching and differentiation into multiple memory B cell subsetsSemantic proximity Read

Development, phenotype, and function of non-conventional B cells.Semantic proximity Read

Unraveling B cell trajectories at single cell resolutionSemantic proximity Read

Age-related dysregulation of B cells in acute respiratory distress syndromeSemantic proximity Read

Single-cell analysis reveals multi-faceted features of B cell development together with age-associated B cell subpopulationsSemantic proximity Read

A Germinal Center–Independent Innate-Like Memory B Cell Compartment of B1 OriginSemantic proximity Read

Distinctions among Circulating Antibody-Secreting Cell Populations, Including B-1 Cells, in Human Adult Peripheral BloodSemantic proximity Read