Article
B-Cell Dysregulation in Idiopathic Nephrotic Syndrome: What We Know and What We Need to Discover.
Frontiers in immunology - 1 Jan 2022
Colucci Manuela, Oniszczuk Julie, Vivarelli Marina, Audard Vincent
Abstract excerpt
The therapeutic efficacy of B-cell depletion by anti-CD20 treatment in pediatric and, more recently, in adult idiopathic nephrotic syndrome patients suggests a key role of B cells in the pathogenesis of the disease. However, their exact role is still unclear. B cells are able to secrete a large variety of antibodies that can protect against infections. However, B-cell dysregulation is well-established in a...
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