Article

Aggresome Formation and Liquid-liquid Phase Separation Independently Induce Cytoplasmic Aggregation of TAR DNA-binding protein 43

2020-06-16

Abstract excerpt

<title>Abstract</title> <bold>Background</bold> Cytoplasmic inclusion of TAR DNA-binding protein 43 (TDP-43) is a pathological hallmark of amyotrophic lateral sclerosis (ALS) and a subtype of frontotemporal lobar degeneration (FTLD). Recent studies have suggested that the formation of cytoplasmic TDP-43 aggregates is dependent on a liquid-liquid phase separation (LLPS) mechanism. However, it is unclear whether...

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Literature Corpus work: a30de5fb-f0a9-50dc-b2b3-5665375c7f28
DOI: 10.21203/rs.3.rs-28758/v1

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