Mutators can increase both the rate of occurrence and specificity of nitrofurantoin resistance mutations

Abstract excerpt

Antimicrobial resistance is a significant global health crisis, with many antibiotics losing effectiveness within a decade of their introduction. The antibiotic nitrofurantoin, however, counters this trend, as it has sustained low resistance rates despite prolonged and widespread use. A key factor behind nitrofurantoin’s success is that resistance requires two independent inactivating mutations in separate genes,...

Topics

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• Anti-Bacterial Agents
• Antibiotic Resistance in Bacteria
• Bacteria
• Bacterial Infections
• Drug Resistance, Bacterial
• Genes, Bacterial
• Mutation
• Urinary Tract Infections Management

Identifiers and source

Literature Corpus work

ee9d2692-f9f7-58f6-855e-72497e468633

DOI

10.1101/2024.10.07.616996